Lichenoid drug reaction to antituberculosis drugs treated through with topical steroids and phototherapy.

نویسندگان

  • Rannakoe J Lehloenya
  • Gail Todd
  • Lesiba Mogotlane
  • Nomphelo Gantsho
  • Carol Hlela
  • Keertan Dheda
چکیده

defined by susceptibility to all of ciprofloxacin, co-trimoxazole and gentamicin) isolates was low (2.9%, 5/175). PCR and sequencing showed that the only extended-spectrum b-lactamase (ESBL)-producing O25b-ST131 isolate had blaCTX-M-14. Our results showed that O25b-ST131 exhibited a wide range of susceptibility patterns. Similar to previous studies, our findings showed that O25b-ST131 isolates were often multidrug resistant and one was a CTX-M producer. However, the only ESBL-producing O25b-ST131 isolate was found to have blaCTX-M-14 instead of blaCTX-M-15. 1,5 Among blood culture E. coli isolates collected in 2007–08, our recent work showed that O25b-ST131 accounted for 25.6% of the ESBL-producing isolates. All ESBL-producing O25b-ST131 isolates had blaCTX-M-14 and none had blaCTX-M-15. 3 As our previous studies revealed, the dissemination of blaCTX-M-14 in O25b-ST131 isolates was associated with the acquisition of an epidemic pHK01 plasmid with FII replicon. In conclusion, this study showed that the O25b-ST131 clonal group is widely distributed among E. coli isolates causing community-acquired UTI in the region. The finding highlights the importance of clonal expansion in dissemination of antimicrobial resistance involving first-line drugs commonly used for treatment of UTIs.

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عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 67 10  شماره 

صفحات  -

تاریخ انتشار 2012